A contribuição do Instituto de Higiene e Medicina Tropical para o conhecimento da infeção pelo Vírus da Imunodeficiência Humana
Palavras-chave:
Infeção VIH, diversidade genética e epidemiologia molecular, resistência aos antirretrovirais, infeção VIH em populações de maior risco, anticorpos neutralizantes
Resumo
Ao longo dos últimos 25 anos, o Instituto de Higiene e Medicina Tropical (IHMT) tem contribuído de forma significativa para o conhecimento da patogénese da infeção pelo vírus da imunodeficiência humana (VIH). Os estudos realizados abrangem vários aspetos da infeção como a caraterização da história evolutiva e diversidade genética do VIH em Portugal, e em alguns países de África; as alterações na dinâmica de transmissão da epidemia do VIH particularmente em populações de maior risco, a análise das mutações virais que conferem resistência aos antirretrovirais (INI e aos PI); caraterização da resposta humoral não neutralizante e neutralizante e o desenvolvimento de vacinas para a infeção VIH.
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Referências
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hybridization assay for the identification of the most prevalent genetic forms of the
human immunodeficiency virus type 1 circulating in Portugal. AIDS research and
human retroviruses 29, 318-328.
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among homosexual men--New York City and California. MMWR Morb Mortal
Wkly Rep 30, 305-308.
2. Barre-Sinoussi, F, Chermann, JC, Rey, F, Nugeyre, M T, Chamaret, S, Gruest,
J, Dauguet, C, Axler-Blin, C, Vezinet-Brun, F, Rouzioux, C, Rozenbaum, W, and
Montagnier, L (1983). Isolation of a T-lymphotropic retrovirus from a patient at
risk for acquired immune deficiency syndrome (AIDS). Science 220, 868-871.
3. Gallo, RC, Salahuddin, SZ, Popovic, M, Shearer, GM, Kaplan, M, Haynes, BF,
Palker, TJ, Redfield, R, Oleske, J, Safai, B, and et al. (1984). Frequent detection and
isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk
for AIDS. Science 224, 500-503.
4. Merson, MH, O’Malley, J, Serwadda, D, and Apisuk, C (2008). The history
and challenge of HIV prevention. Lancet 372, 475-488.
5. Clavel, F, Guetard, D, Brun-Vezinet, F, Chamaret, S, Rey, MA, Santos-Ferreira,
MO, Laurent, AG, Dauguet, C, Katlama, C, Rouzioux, C, and et al. (1986).
Isolation of a new human retrovirus from West African patients with AIDS. Science
233, 343-346.
6. Clavel, F, Mansinho, K, Chamaret, S, Guetard, D, Favier, V, Nina, J, Santos-
-Ferreira, MO, Champalimaud, JL, and Montagnier, L (1987). Human immunodeficiency
virus type 2 infection associated with AIDS in West Africa. The New
England journal of medicine 316, 1180-1185.
7. Faria, NR, Rambaut, A, Suchard, MA, Baele, G, Bedford, T, Ward, MJ, Tatem,
AJ, Sousa, JD, Arinaminpathy, N, Pepin, J, Posada, D, Peeters, M, Pybus, OG, and
Lemey, P (2014). HIV epidemiology. The early spread and epidemic ignition of
HIV-1 in human populations. Science 346, 56-61.
8. Santiago, M L, Range, F, Keele, B F, Li, Y, Bailes, E, Bibollet-Ruche, F, Fruteau,
C, Noe, R, Peeters, M, Brookfield, JF, Shaw, GM, Sharp, PM, and Hahn, BH
(2005). Simian immunodeficiency virus infection in free-ranging sooty mangabeys
(Cercocebus atys atys) from the Tai Forest, Cote d’Ivoire: implications for the origin
of epidemic human immunodeficiency virus type 2. Journal of virology 79,
12515-12527.
9. Gomes, P, Abecasis, A, Almeida, M, Camacho, R, and Mansinho, K (2003).
Transmission of HIV-2. The Lancet. Infectious diseases 3, 683-684.
10. Robertson, DL, Anderson, JP, Bradac, JA, Carr, JK, Foley, B, Funkhouser, RK,
Gao, F, Hahn, BH, Kalish, ML, Kuiken, C, Learn, GH, Leitner, T, McCutchan, F,
Osmanov, S, Peeters, M, Pieniazek, D, Salminen, M, Sharp, PM, Wolinsky, S, and
Korber, B (2000). HIV-1 nomenclature proposal. Science 288, 55-56.
11. Rambaut, A, Posada, D, Crandall, KA, and Holmes, EC (2004). The causes
and consequences of HIV evolution. Nature reviews. Genetics 5, 52-61.
12. Gilbert, M T, Rambaut, A, Wlasiuk, G, Spira, TJ, Pitchenik, AE, and Worobey,
M (2007). The emergence of HIV/AIDS in the Americas and beyond. Proceedings
of the National Academy of Sciences of the United States of America 104, 18566-
18570.
13. Tristem, M, Mansinho, K, Champalimaud, JL, Ayres, L, and Karpas, A (1989).
Six new isolates of human immunodeficiency virus type 2 (HIV-2) and the molecular
characterization of one (HIV-2CAM2). The Journal of general virology 70 ( Pt
2), 479-484.
14. Piedade, J, Venenno, T, Prieto, E, Albuquerque, R, Esteves, A, Parreira, R, and
Canas-Ferreira, WF (2000). Longstanding presence of HIV-2 infection in Guinea-
-Bissau (West Africa). Acta tropica 76, 119-124.
15. Parreira, R, Piedade, J, Domingues, A, Lobao, D, Santos, M, Venenno, T, Baptista,
JL, Mussa, SA, Barreto, AT, Baptista, AJ, and Esteves, A. (2006). Genetic characterization
of human immunodeficiency virus type 1 from Beira, Mozambique.
Microbes and infection / Institut Pasteur 8, 2442-2451.
16. Esteves, A, Parreira, R, Venenno, T, Franco, M, Piedade, J, Germano De Sousa,
J, and Canas-Ferreira, W. F. (2002). Molecular epidemiology of HIV type 1 infection
in Portugal: high prevalence of non-B subtypes. AIDS research and human
retroviruses 18, 313-325.
17. Abecasis, A, Paraskevis, D, Epalanga, M, Fonseca, M, Burity, F, Bartolomeu,
J, Carvalho, AP, Gomes, P, Vandamme, AM, and Camacho, R (2005). HIV-1 genetic
variants circulation in the North of Angola. Infection, genetics and evolution :
journal of molecular epidemiology and evolutionary genetics in infectious diseases
5, 231-237.
18. Abecasis, AB, Wensing, AM, Paraskevis, D, Vercauteren, J, Theys, K, Van de Vijver,
DA, Albert, J, Asjo, B, Balotta, C, Beshkov, D, Camacho, RJ, Clotet, B, De Gascun,
C, Griskevicius, A, Grossman, Z, Hamouda, O, Horban, A, Kolupajeva, T, Korn,
K, Kostrikis, LG, Kucherer, C, Liitsola, K, Linka, M, Nielsen, C, Otelea, D, Paredes,
R, Poljak, M, Puchhammer-Stockl, E, Schmit, JC, Sonnerborg, A, Stanekova, D,
Stanojevic, M, Struck, D, Boucher, CA, and Vandamme, AM (2013). HIV-1 subtype
distribution and its demographic determinants in newly diagnosed patients in Europe
suggest highly compartmentalized epidemics. Retrovirology 10, 7.
19. Palma, AC, Araújo, F, Duque, V, Borges, F, Paixão, MT, Camacho, R, and
Network, PS (2007). Molecular epidemiology and prevalence of drug resistance-
-associated mutations in newly diagnosed HIV-1 patients in Portugal. Infect Genet
Evol 7, 391-398.
20. Bártolo, I, Abecasis, AB, Borrego, P, Barroso, H, McCutchan, F, Gomes, P,
Camacho, R, and Taveira, N (2011). Origin and epidemiological history of HIV-1
CRF14_BG. PLoS One 6, e24130.
21. Esteves, A, Parreira, R, Piedade, J, Venenno, T, Franco, M, Germano de Sousa,
J, Patricio, L, Brum, P, Costa, A, and Canas-Ferreira, WF (2003). Spreading of HIV-
1 subtype G and envB/gagG recombinant strains among injecting drug users in
Lisbon, Portugal. AIDS research and human retroviruses 19, 511-517.
22. Freitas, FB, Esteves, A, Piedade, J, and Parreira, R (2013). Novel multiregion
hybridization assay for the identification of the most prevalent genetic forms of the
human immunodeficiency virus type 1 circulating in Portugal. AIDS research and
human retroviruses 29, 318-328.
23. Chaisson, RE, Allain, JP, Leuther, M, and Volberding, PA (1986). Significant
changes in HIV antigen level in the serum of patients treated with azidothymidine.
The New England journal of medicine 315, 1610-1611.
24. Larder, BA, Darby, G, and Richman, DD (1989). HIV with reduced sensitivity
to zidovudine (AZT) isolated during prolonged therapy. Science 243, 1731-1734.
25. Abecasis, AB, Vandamme, AM, and Lemey, P (2009). Quantifying differences
in the tempo of human immunodeficiency virus type 1 subtype evolution. Journal
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Publicado
2018-09-03
Como Citar
1.
Abecasis AB, Dias S, Marcelino JM. A contribuição do Instituto de Higiene e Medicina Tropical para o conhecimento da infeção pelo Vírus da Imunodeficiência Humana. ihmt [Internet]. 3Set.2018 [citado 8Jul.2024];13:37-5. Available from: https://anaisihmt.com/index.php/ihmt/article/view/170
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